Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer.

@article{Camorani2014InhibitionOR,
  title={Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer.},
  author={Simona Camorani and Carla Lucia Esposito and Anna Rienzo and Silvia Catuogno and Margherita Iaboni and Gerolama Condorelli and Vittorio de Franciscis and Laura Cerchia},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014},
  volume={22 4},
  pages={828-41}
}
Platelet-derived growth factor receptor β (PDGFRβ) is a cell-surface tyrosine kinase receptor implicated in several cellular processes including proliferation, migration, and angiogenesis. It represents a compelling therapeutic target in many human tumors, including glioma. A number of tyrosine kinase inhibitors under development as antitumor agents have been found to inhibit PDGFRβ. However, they are not selective as they present multiple tyrosine kinase targets. Here, we report a novel PDGFR… CONTINUE READING