Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain

  title={Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain},
  author={Patrick Wigge and Yvonne Vallis and Harvey T McMahon},
  journal={Current Biology},
BACKGROUND Receptor-mediated endocytosis appears to require the GTP-binding protein dynamin, but the process by which dynamin is recruited to clathrin-coated pits remains unclear. Dynamin contains several proline-rich clusters that bind to Src homology 3 (SH3) domains, which are short modules found in many signalling proteins and which mediate protein-protein interactions. Amphiphysin, a protein that is highly expressed in the brain, interacts with dynamin in vitro, as do Grb2 and many other… CONTINUE READING
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