Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.

@article{Mahley1980InhibitionOR,
  title={Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.},
  author={Robert W. Mahley and Karl H. Weisgraber and George W. Melchior and Thomas L. Innerarity and K S Holcombe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 1},
  pages={225-9}
}
Reductive methylation of at least 30% of the lysine residues or 1,2-cyclohexanedione modification of 45% of the arginine residues prevented low density lipoproteins (LDL) from binding to cell surface receptors of fibroblasts in vitro, without significantly altering other physical or chemical properties of the LDL. When rat or human LDL with more than 30% of the lysine residues methylated were injected intravenously into rats, the clearance of these lipoproteins from the plasma was slowed… CONTINUE READING

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