Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7.

@article{Kimura2008InhibitionOR,
  title={Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7.},
  author={Kenya Kimura and Sachiko Ito and Masato Nagino and Ken-ichi Isobe},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={372 1},
  pages={272-5}
}
In order to examine the endoplasmic reticulum responses in macrophages, we stimulate macrophage cell line RAW 264.7 by LPS. We found the phosphorylation of eukaryotic initiation factor eIF2alpha and the expression of ATF4, GADD34, and GADD153 in RAW 264.7 cells in late time by the relatively large amount of LPS stimulation. Unexpectedly LPS in the presence of ROS inhibitor N-acetyl-L-cysteine rapidly induced phosphorylation of eIF2alpha and induction of GADD34 expression. We measured intra… CONTINUE READING

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