Inhibition of rat testicular nuclear kinesins (krp2; KIFC5A) by acrylamide as a basis for establishing a genotoxicity threshold.

Abstract

Acrylamide is a toxic substance that induces a variety of cellular responses including neurotoxicity, male reproductive toxicity, tumorigenicity, clastogenicity, and DNA alkylation. Evidence is provided that inhibition of the microtubule motor protein kinesin is responsible for acrylamide-induced clastogenicity and aneuploidy. Two kinesin motors, KIFC5A and… (More)
DOI: 10.1021/jf703746f

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