Inhibition of rat pituitary tumor cell proliferation by benzodiazepines in vitro.

@article{KunertRadek1994InhibitionOR,
  title={Inhibition of rat pituitary tumor cell proliferation by benzodiazepines in vitro.},
  author={Jolanta Kunert-Radek and Henryk Stępień and Marek Pawlikowski},
  journal={Neuroendocrinology},
  year={1994},
  volume={59 1},
  pages={92-6}
}
The effect of various benzodiazepines (peripheral-type receptor ligands: Ro 5-4864, PK 11135; central-type receptor ligands: clonazepam, Ro 15-1788, Ro 15-4513; mixed type: diazepam) on the proliferation of estrogen-induced rat pituitary prolactin-secreting tumor cells was studied in vitro. [3H]thymidine incorporation into DNA was used as an index of cell proliferation. It was found that tested peripheral- and mixed-type benzodiazepine receptor ligands significantly suppressed the pituitary… CONTINUE READING

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