Inhibition of rat neutrophil functional responses by azapropazone, an anti-gout drug.

@article{Mackin1986InhibitionOR,
  title={Inhibition of rat neutrophil functional responses by azapropazone, an anti-gout drug.},
  author={William M. Mackin and S M Rakich and C L Marshall},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 6},
  pages={
          917-22
        }
}
Azapropazone at concentrations of 0.1 to 1 mM inhibited by 30-70% rat neutrophil migration, aggregation, and degranulation in response to the synthetic chemotactic peptide fMet-Leu-Phe. Binding studies using fNle-Leu-[3H]Phe, a radiolabeled analog of fMet-Leu-Phe, showed that azapropazone did not inhibit these responses by interfering with fMet-Leu-Phe binding. Azapropazone also decreased both the apparent rate of production and maximal levels of superoxide anion (O2-) generated by cells… Expand
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