Inhibition of rat liver glutathione S-transferases by piriprost: kinetics of the inhibition and preliminary evidence that piriprost may be a poor alternative substrate for these enzymes.


The administration of tritiated piriprost, an inhibitor of leukotriene formation, to rats resulted in its rapid excretion. Some 90 percent of the initial dose was excreted in the feces and only five to six percent were recovered in the urine, regardless of the route of administration of the compound. The finding of significant, though low, residual activity… (More)


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