Inhibition of rat hypothalamic somatostatin release by somatostatin: evidence for somatostatin ultrashort loop feedback.

@article{Richardson1986InhibitionOR,
  title={Inhibition of rat hypothalamic somatostatin release by somatostatin: evidence for somatostatin ultrashort loop feedback.},
  author={S. B. Richardson and S. Twente},
  journal={Endocrinology},
  year={1986},
  volume={118 5},
  pages={2076-82}
}
To determine whether hypothalamic somatostatin (SRIF) release might be modulated by a negative feedback loop, we examined the effects of exogenous SRIF on the release of SRIF immunoreactivity from dispersed adult rat hypothalamic cells. Added SRIF-(1-14) caused dose-dependent inhibition of endogenous SRIF release in this system (IC50, 140 pM). SRIF-(1-28) and Tyr1-SRIF also inhibited SRIF release, whereas other peptides present in the hypothalamus were without demonstrable effects when tested… CONTINUE READING

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