Inhibition of rat cardiac fibroblast growth by cAMP – but not by cGMP-dependent protein kinase

@article{Marienfeld2001InhibitionOR,
  title={Inhibition of rat cardiac fibroblast growth by cAMP – but not by cGMP-dependent protein kinase},
  author={Uta Marienfeld and Ulrich Walter and Andreas Simm},
  journal={Basic Research in Cardiology},
  year={2001},
  volume={96},
  pages={184-191}
}
Cardiac fibroblasts play a critical role in the process of pathophysiological cardiac hypertrophy as the cell type responsible for fibrosis. Whereas many growth factors and hormones are thought to be involved, possible crosstalks between signal transduction pathways are not well defined. Therefore we investigated the influence of cAMP- and cGMP-dependent protein kinases (cAK, CGK) on platelet derived growth factor (PDGF) stimulated growth of primary cardiac fibroblasts from adult rats. We show… CONTINUE READING
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