Inhibition of rat brain monoamine oxidase by some analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion.

@article{Arai1986InhibitionOR,
  title={Inhibition of rat brain monoamine oxidase by some analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion.},
  author={Yasuhiro Arai and Hiroyasu Kinemuchi and N Hamamichi and Naotake Satoh and Takeshi Tadano and Kensuke Kisara},
  journal={Neuroscience letters},
  year={1986},
  volume={66 1},
  pages={43-8}
}
To clarify the essential chemical structures of the neurotoxins, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its oxidized product, 1-methyl-4-phenylpyridinium ion (MPP+), that govern nigrostriatal dopamine neuron toxicity, interactions of several structurally related compounds of MPTP or MPP+ with monoamine oxidase (MAO) in rat forebrain… CONTINUE READING