Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA

@article{Resnicoff1996InhibitionOR,
  title={Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA},
  author={Mariana Resnicoff and Weiping Li and Saroj Basak and Dorothee M Herlyn and Renato Baserga and Raphael Rubin},
  journal={Cancer Immunology, Immunotherapy},
  year={1996},
  volume={42},
  pages={64-68}
}
 The expression of insulin-like growth factor I receptor (IGF-IR) antisense mRNA inhibits the growth of C6 rat glioblastoma cells both in vitro and in vivo [Cancer Res (1994) 54: 2218]. Moreover, the injection of C6 cells expressing an antisense mRNA to the IGF-IR into syngeneic rats prevents subsequent wild-type tumorigenesis and induces regression of established tumors. For the study of immune function in syngeneic rats, C6 cells expressing either IGF-IR sense or IGF-IR antisense mRNA were… CONTINUE READING