Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx.

  title={Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx.},
  author={Junko Sugatani and T. Iwai and M Watanabe and Kiyotaka Machida and T P Tanaka and Toshiyasu Maeda and Misawa Miwa},
  journal={Biochemical pharmacology},
  volume={60 2},
Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry
Toborinone and olprinone inhibit human platelet aggregation, though these concentrations are higher than their therapeutic plasma concentrations, and the inhibitory effects of both drugs are related to the inhibition of bothCa2+ release and Ca2+ entry through [cAMP]i elevation.
Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function.
Among nucleoside 5'-alkylphosphates, uridine 5'-eicosylph phosphate (UMPC20) selectively and predominantly inhibited ascospore formation of the yeast cells.
Involvement of oxidative stress induction in Na+ toxicity and its relation to the inhibition of a Ca2+ -dependent but calcineurin-independent mechanism in Saccharomyces cerevisiae.
UMPC16, but not CsA, accelerated mitochondrial reactive oxygen species (ROS) generation in combination with Na+, suggesting its inhibition of a Ca2+ -dependent but calcineurin-independent mechanism for protection against Na+ toxicity.
Selective inhibition of embryonic development in starfish by long-chain alkyl derivatives of UMP, TMP and AMP
Adenosine 5′-laurylphosphate was evaluated as a novel class of inhibitor that can arrest the embryos exactly at the late gastrula stage, absolutely inhibiting cell differentiation involved in the development of gastrointestinal tract.


Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
The results indicate that continuous binding of PAF to its receptor is necessary for prolonged platelet aggregation, which may be mediated through an unknown signaling system for a long-term cell response rather than a transient signaling system.
Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.
The effects of arachidonic acid and thrombin on calcium movements have been studied in fura-2-loaded platelets by a procedure which allows simultaneous monitoring of the uptake of manganese, a
Molecular Basis for ADP-induced Platelet Activation
The role of the P2Y1 receptor is demonstrated in ADP-induced platelet shape change and calcium mobilization and support the idea that several P2 receptors are involved in the regulation of different aspects of platelet stimulus-response coupling.
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen.
Results indicate that, whereas ionomycin requires Ca2+ in the microM range for arachidonate liberation, collagen, notably in the presence of indomethacin, does so at basal Ca2- levels.
Ristocetin-induced platelet agglutination stimulates GPIIb/IIIa-dependent calcium influx.
The results suggest that platelet clumping induced by vWF binding to GPIb is responsible for GPIIb-IIIa dependent Ca2+ influx.
Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx.
The existence of a PtdIns(3,4,5)P3-dependent Ca2+ entry system on platelet membranes is supported by the partial inhibition of thrombin-induced Ca 2+ influx by wortmannin, and this study bears out the notion that individual PI 3-kinase lipid products play distinct roles in the regulation of cellular functions.