Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx.

@article{Sugatani2000InhibitionOR,
  title={Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx.},
  author={Junko Sugatani and T. Iwai and M Watanabe and Kiyotaka Machida and T P Tanaka and Toshiyasu Maeda and Misawa Miwa},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 2},
  pages={
          197-205
        }
}
Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry
TLDR
Toborinone and olprinone inhibit human platelet aggregation, though these concentrations are higher than their therapeutic plasma concentrations, and the inhibitory effects of both drugs are related to the inhibition of bothCa2+ release and Ca2+ entry through [cAMP]i elevation.
Evaluation of uridine 5'-eicosylphosphate as a stimulant of cyclic AMP-dependent cellular function.
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Among nucleoside 5'-alkylphosphates, uridine 5'-eicosylph phosphate (UMPC20) selectively and predominantly inhibited ascospore formation of the yeast cells.
Involvement of oxidative stress induction in Na+ toxicity and its relation to the inhibition of a Ca2+ -dependent but calcineurin-independent mechanism in Saccharomyces cerevisiae.
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UMPC16, but not CsA, accelerated mitochondrial reactive oxygen species (ROS) generation in combination with Na+, suggesting its inhibition of a Ca2+ -dependent but calcineurin-independent mechanism for protection against Na+ toxicity.
Selective inhibition of embryonic development in starfish by long-chain alkyl derivatives of UMP, TMP and AMP
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Adenosine 5′-laurylphosphate was evaluated as a novel class of inhibitor that can arrest the embryos exactly at the late gastrula stage, absolutely inhibiting cell differentiation involved in the development of gastrointestinal tract.

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