Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

@article{Hentzer2002InhibitionOQ,
  title={Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.},
  author={Morten Hentzer and Kathrin Riedel and Thomas Bovbjerg Rasmussen and Arne Heydorn and Jens Bo Andersen and Matthew R. Parsek and Scott A Rice and Leo Eberl and Soeren Molin and Niels H\oiby and Staffan J. Kjelleberg and Michael C Givskov},
  journal={Microbiology},
  year={2002},
  volume={148 Pt 1},
  pages={87-102}
}
Novel molecular tools have been constructed which allow for in situ detection of N-acyl homoserine lactone (AHL)-mediated quorum sensing in Pseudomonas aeruginosa biofilms. The reporter responds to AHL activation of LasR by expression of an unstable version of the green-fluorescent protein (Gfp). Gfp-based reporter technology has been applied for non-destructive, single-cell-level detection of quorum sensing in laboratory-based P. aeruginosa biofilms. It is reported that a synthetic halogenated… CONTINUE READING
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