Inhibition of queuine uptake in cultured human fibroblasts by phorbol-12,13-didecanoate.

@article{Elliott1985InhibitionOQ,
  title={Inhibition of queuine uptake in cultured human fibroblasts by phorbol-12,13-didecanoate.},
  author={Mark S. Elliott and Ronald W. Trewyn and Jon R. Katze},
  journal={Cancer research},
  year={1985},
  volume={45 3},
  pages={1079-85}
}
The modified base queuine is inserted posttranscriptionally into the first position of the anticodon of tyrosine tRNA, histidine tRNA, asparginine tRNA, and aspartic acid tRNA. Phorbol-12,13-didecanoate (PDD) effects a decrease in the queuine content of tRNA in cultured human foreskin fibroblasts. The present data suggest that this results from a PDD-mediated inhibition of queuine uptake. Nonsaturable uptake was observed for tritiated dihydroqueuine (rQT3) for up to 2 hr at 10 to 1000 nM… CONTINUE READING