Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophy.

@article{Barnes2013InhibitionOP,
  title={Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophy.},
  author={Laurent Barnes and Fr{\'e}d{\'e}rique Ino and Fabienne Jaunin and Jean H. Saurat and Dr. Gazanfer Kaya},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 4},
  pages={
          1017-26
        }
}
The main limitation of using topical corticosteroids in dermatology is their atrophic effects on the skin. We have previously proposed a molecular platform composed of CD44, EGFR, and hyaluronate synthase (HAS) that is functionally defective in dermatoporosis, a chronic cutaneous insufficiency/fragility syndrome. In this study, we explored the molecular mechanisms of the skin atrophy induced by corticosteroids. We observed an important skin atrophy and a significant decrease of hyaluronic acid… CONTINUE READING
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