Inhibition of pulmonary eosinophilia does not necessarily prevent the airway hyperresponsiveness induced by Sephadex beads.

@article{Matsubara1998InhibitionOP,
  title={Inhibition of pulmonary eosinophilia does not necessarily prevent the airway hyperresponsiveness induced by Sephadex beads.},
  author={Satoko Matsubara and Kazuo Fushimi and Koji Ogawa and Hideo Kikkawa and Akinori Nakata and Rie Kameda and Minoru Kikuchi and Kazuyo Naito and Katsuo Ikezawa},
  journal={International archives of allergy and immunology},
  year={1998},
  volume={116 1},
  pages={
          67-75
        }
}
BACKGROUND The Lewis rat among highly inbred strains exhibits significant airway hyperresponsiveness (AHR) following intravenous administration of Sephadex G-200 (Sephadex). The aim of this study was to investigate the association of Sephadex-induced AHR with changes in airway inflammation in Lewis rats. METHODS A suspension (0.5 mg/ml/rat) of Sephadex was intravenously administered to male Lewis rats on days 0, 2 and 5. Measurement of airway responsiveness to serotonin, bronchoalveolar… CONTINUE READING
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