Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis.

@article{Daouk1995InhibitionOP,
  title={Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis.},
  author={G H Daouk and Run{\'o}lfur P{\'a}lsson and M. Amin Arnaout},
  journal={Kidney international},
  year={1995},
  volume={47 6},
  pages={1528-36}
}
Detection of circulating antineutrophil cytoplasmic antibodies (ANCA) to the neutrophil serine proteinase, proteinase 3 (PR3), has proven valuable for the diagnosis of Wegener's granulomatosis (WG). However, the importance of these autoantibodies in the pathogenesis of WG remains unknown. It was recently reported that anti-PR3 autoantibodies (PR3-ANCA) from some patients with WG inhibit the proteolytic activity of PR3 and interfere with the inactivation of PR3 by the physiologic inhibitor… CONTINUE READING
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