Inhibition of protein tyrosine phosphatases suppresses P-selectin exocytosis in activated human platelets.

Abstract

P-selectin (CD62P), a cell adhesion molecule for most leukocytes, is stored in the alpha-granules of platelets and the Weibel-Palade bodies of endothelial cells. Upon thrombogenic and inflammatory challenges, P-selectin is rapidly expressed, by exocytosis, on activated platelets and stimulated endothelial cells. However, little is known with regard to the… (More)

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