Inhibition of protein synthesis by exogenous A2'p5'A2'p5'A (2-5 A core) and its bis-phosphoramidate analog in intact mouse lymphocytes, hepatocytes and bone marrow cells.

@article{Jurovk1981InhibitionOP,
  title={Inhibition of protein synthesis by exogenous A2'p5'A2'p5'A (2-5 A core) and its bis-phosphoramidate analog in intact mouse lymphocytes, hepatocytes and bone marrow cells.},
  author={M. Jurov{\vc}{\'i}k and J. Smrt},
  journal={FEBS letters},
  year={1981},
  volume={133 1},
  pages={178-80}
}
Interferon-treated cells are capable of synthesizing at least 3 enzymes which are involved in normal cell proliferation and anti-viral immunity [l-4]. One of these enzymes, interferonand dsRNA-dependent oligoisoadenylate synthetase is responsible for a polymerization of ATP resulting in a series of (2’ + 5’)-linked oligoadenylic acid 5’-triphosphates. The major active species is the trimer, pppA2’p5’A2’p5’A(2-5 A), which is able to inhibit protein synthesis in cell-free system at… CONTINUE READING