Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of nitric oxide production.

@article{Cossenza2006InhibitionOP,
  title={Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of nitric oxide production.},
  author={Marcelo Cossenza and Daniel Veloso Cadilhe and Rodrigo N Coutinho and Roberto Paes-de-Carvalho},
  journal={Journal of neurochemistry},
  year={2006},
  volume={97 5},
  pages={1481-93}
}
The synthesis of nitric oxide (NO) is limited by the intracellular availability of L-arginine. Here we show that stimulation of NMDA receptors promotes an increase of intracellular L-arginine which supports an increase in the production of NO. Although L-[3H]arginine uptake measured in cultured chick retina cells incubated in the presence of cycloheximide (CHX, a protein synthesis inhibitor) was inhibited approximately 75% at equilibrium, quantitative thin-layer chromatography analysis showed… CONTINUE READING
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