Inhibition of protein synthesis by 2′–5′ linked adenine oligonucleotides in intact cells

@article{Williams1978InhibitionOP,
  title={Inhibition of protein synthesis by 2′–5′ linked adenine oligonucleotides in intact cells},
  author={Bryan R. G. Williams and Ian M. Kerr},
  journal={Nature},
  year={1978},
  volume={276},
  pages={88-90}
}
A SERIES of 2–5 linked oligoadenylic acid triphosphate (2–5A) inhibitors of cell-free protein synthesis are formed from ATP by an enzyme (2–5A synthetase) activated in interferon-treated cell extracts or rabbit reticulocyte lysates by double-stranded RNA1–4. The major active species is the trimer, pppA2′p5′A2′p5′A. Cell-free protein synthesis is inhibited… CONTINUE READING