Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation

@inproceedings{AparicioSiegmund2014InhibitionOP,
  title={Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation},
  author={Samadhi Aparicio-Siegmund and Jan Sommer and Niloufar Monhasery and Ralf Schwanbeck and Eric J. Keil and David Finkenst{\"a}dt and Klaus Pfeffer and Stefan Rose-John and J{\"u}rgen Scheller and Christoph Garbers},
  booktitle={Oncotarget},
  year={2014}
}
The Janus kinase / signal transducer and activator of transcription (Jak/STAT) pathway can be activated by many different cytokines, among them all members of the Interleukin (IL-)6 family. Dysregulation of this pathway, resulting in its constitutive activation, is associated with chronic inflammation and cancer development. In the present study, we show that activity of protein kinase II (CK2), a ubiquitously expressed serine/threonine kinase, is needed for induced activation of STAT1 and… CONTINUE READING

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