Inhibition of protein kinase C zeta blocks the attachment of stable microtubules to kinetochores leading to abnormal chromosome alignment.

@article{Liu2006InhibitionOP,
  title={Inhibition of protein kinase C zeta blocks the attachment of stable microtubules to kinetochores leading to abnormal chromosome alignment.},
  author={Xiu Fen Liu and Xiaozhen Xie and Toru Miki},
  journal={Cellular signalling},
  year={2006},
  volume={18 12},
  pages={2314-23}
}
The attachment of spindle microtubules to kinetochores is crucial for accurate segregation of chromosomes to daughter cells during mitosis. While a growing number of proteins involving this step are being identified, its molecular mechanisms are still not clear. Here we show that protein kinase C zeta (PKCzeta) is localized at the mitotic spindle during mitosis and plays a role in stable kinetochore-microtubule attachment. Striking staining for PKCzeta was observed at the mitotic spindle and… CONTINUE READING