Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine.

@article{Chao1998InhibitionOP,
  title={Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine.},
  author={M D Chao and I S Chen and Jiin Tsuey Cheng},
  journal={Planta medica},
  year={1998},
  volume={64 7},
  pages={662-3}
}
Protein kinase C (PKC) is regarded as an important signal in cellular responses. Chelerythrine, the alkaloid in Zanthoxylum simulans, was recently introduced as a specific blocker of PKC phosphorylation. The present study demonstrated an inhibitory effect of chelerythrine on the translocation of PKC from cytosol to membrane using Western blotting analysis. An increase of PKC translocation from cytosol to the membrane was observed in isolated ileal synaptosomes incubated with phorbol 12… CONTINUE READING

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