Inhibition of protein kinase C in diabetic nephropathy--where do we stand?

@article{Menne2009InhibitionOP,
  title={Inhibition of protein kinase C in diabetic nephropathy--where do we stand?},
  author={Jan Menne and Matthias Meier and Joon-Keun Park and Hermann Haller},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2009},
  volume={24 7},
  pages={
          2021-3
        }
}
Hyperglycaemia plays a key role in the pathogenesis of microvascular diabetic complications. More than 20 years ago, it was described that the activation of the protein kinase C (PKC) system by hyperglycaemia may represent an important mediator of glucotoxicity in diabetic nephropathy [1,2]. The putative intracellular mechanism is the glucoseinduced de novo synthesis of diacylglycerol that is one of the intracellular activators of PKC. Although hyperglycaemia is a major PKC activator, several… CONTINUE READING

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