Inhibition of protein kinase C by resveratrol.

  title={Inhibition of protein kinase C by resveratrol.},
  author={Simon J. Slater and Jodie L Seiz and Anthony C Cook and Brigid A Stagliano and Christopher J Buzas},
  journal={Biochimica et biophysica acta},
  volume={1637 1},
Evidence is emerging that resveratrol (RV), a polyphenolic phytoaxelin present in dietary sources including red wine, may protect against atherosclerosis and cardiovascular disease by enhancing the integrity of the endothelium. In this study, the possibility that such beneficial effects of RV may arise from a modulation of protein kinase C (PKC)-mediated signaling was investigated by determining the effects of RV on the in vitro activities of PKC isozymes. It was found that the Ca(2+)-dependent… CONTINUE READING


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