Inhibition of protein kinase B/Akt. implications for cancer therapy.

@article{Hill2002InhibitionOP,
  title={Inhibition of protein kinase B/Akt. implications for cancer therapy.},
  author={Michelle M. Hill and Brian A. Hemmings},
  journal={Pharmacology & therapeutics},
  year={2002},
  volume={93 2-3},
  pages={243-51}
}
Protein kinase B (PKB, also called Akt) is an important regulator of cell proliferation and survival. Amplification of genes encoding PKB isoforms has been found in several types of human cancers. In addition, mutations in the phosphatase and tensin homolog deleted on chromosome ten (PTEN), one of the most frequently mutated tumor suppressor genes, results in elevated PKB activity. PKB has a wide range of cellular targets, and the oncogenicity of PKB arises from activation of both proliferative… CONTINUE READING

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