Inhibition of protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.

@article{Subramanyam2010InhibitionOP,
  title={Inhibition of protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.},
  author={Muthangi Subramanyam and Nobuyuki Takahashi and Yuichi Hasegawa and T. Mohri and Yasunobu Okada},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 9},
  pages={6109-17}
}
Most animal cell types regulate their cell volume after an osmotic volume change. The regulatory volume increase (RVI) occurs through uptake of NaCl and osmotically obliged water after osmotic shrinkage. However, apoptotic cells undergo persistent cell shrinkage without showing signs of RVI. Persistence of the apoptotic volume decrease is a prerequisite to apoptosis induction. We previously demonstrated that volume regulation is inhibited in human epithelial HeLa cells stimulated with the… CONTINUE READING
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ASK1 Is Involved in Apoptotic Inhibition of RVI

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