Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGF beta 1.

@article{Hashimoto2003InhibitionOP,
  title={Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGF beta 1.},
  author={Osamu Hashimoto and Takato Ueno and Rina Kimura and Motoaki Ohtsubo and Toru M Nakamura and Hironori Koga and Takuji Torimura and Sanae Uchida and Katsumi Yamashita and Michio Sata},
  journal={Molecular carcinogenesis},
  year={2003},
  volume={36 4},
  pages={171-82}
}
Transforming growth factor beta1 (TGF beta 1)-induced G2 arrest was observed when a proliferation inhibitory function of the retinoblastoma protein (Rb) was compromised, but the mechanism underlying the G2 arrest was poorly characterized compared with that of G1 arrest. In the present study, we characterized G2 arrest induced by TGF beta1 (1 ng/mL) in the Rb-negative hepatoma cell line (Hep3B) and compared with G1 arrest in the Rb-positive hepatoma cell line (Huh7). Activities of cyclin… CONTINUE READING
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