Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes.

@article{Mutomba1997InhibitionOP,
  title={Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes.},
  author={M C Mutomba and Wing-Keung To and William C Hyun and Ching Chiung Wang},
  journal={Molecular and biochemical parasitology},
  year={1997},
  volume={90 2},
  pages={491-504}
}
Proteasomes are one of the cellular complexes controlling protein degradation from archaebacteria to mammalian cells. We recently purified and characterized the catalytic core of the proteasome, the 20S form, from Trypanosoma brucei, a flagellated protozoa which causes African trypanosomiasis. To identify the role of proteasomes in African trypanosomes, we… CONTINUE READING