Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram.

@article{Lvborg2006InhibitionOP,
  title={Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram.},
  author={Henrik L{\"o}vborg and Fredrik Oberg and Linda Rickardson and Joachim Gullbo and P. -{\AA}. Nygren and Rolf Larsson},
  journal={International journal of cancer},
  year={2006},
  volume={118 6},
  pages={1577-80}
}
The proteasome pathway is an important target for anticancer drug development. Here, we identify the antialcoholism drug disulfiram and its analogue pyrrolidine dithiocarbamate (PDTC) as inhibitors of the 26S proteasome activity in a cell-based screening assay. As expected for proteasome inhibitors, these compounds also inhibited TNF-alpha-induced nuclear factor-KappaB (NF-KappaB) translocation and were cytotoxic. Disulfiram was more cytotoxic against chronic lymphocytic leukemia cells compared… CONTINUE READING

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