Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway.

@article{Jana2004InhibitionOP,
  title={Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway.},
  author={Nihar R Jana and Priyanka Tiwari Dikshit and Anand Goswami and Nobuyuki Nukina},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 12},
  pages={11680-5}
}
Curcumin is a natural polyphenolic compound having an antiproliferative property, which recent evidence suggests is due to its ability to induce apoptosis. However, the molecular mechanisms through which curcumin induces apoptosis are not fully understood. Here, we report that the curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome system. Exposure of curcumin to the mouse neuro 2a cells causes a dose-dependent decrease in proteasome activity and an… CONTINUE READING
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