Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease.

@article{Raymond2006InhibitionOP,
  title={Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease.},
  author={Gregory J. Raymond and Emily A. Olsen and Kil Sun Lee and Lynne D. Raymond and Patrick K. Bryant and Gerald S. Baron and Winslow S. Caughey and David A. Kocisko and Linda E. McHolland and Cynthia Favara and Jan P. M. Langeveld and Fred G. van Zijderveld and Richard T. Mayer and Michael A Miller and Elizabeth S. Williams and Byron Caughey},
  journal={Journal of virology},
  year={2006},
  volume={80 2},
  pages={596-604}
}
Chronic wasting disease (CWD) is an emerging transmissible spongiform encephalopathy (prion disease) of North American cervids, i.e., mule deer, white-tailed deer, and elk (wapiti). To facilitate in vitro studies of CWD, we have developed a transformed deer cell line that is persistently infected with CWD. Primary cultures derived from uninfected mule deer brain tissue were transformed by transfection with a plasmid containing the simian virus 40 genome. A transformed cell line (MDB) was… CONTINUE READING
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