Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat.

Abstract

Our objective was to test the effect of inhibition of thromboxane synthase versus inhibition of cyclooxygenase (COX)-1/2 on pulmonary gas exchange and heart function during simulated pulmonary embolism (PE) in the rat. PE was induced in rats via intrajugular injection of polystyrene microspheres (25 micro m). Rats were randomized to one of three… (More)

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@article{Jones2003InhibitionOP, title={Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat.}, author={Alan E. Jones and John Albert Watts and Jacob P Debelak and Lisa R. Thornton and John G. Younger and Jeffrey A. Kline}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2003}, volume={284 6}, pages={L1072-81} }