Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1.

@article{Nolan1986InhibitionOP,
  title={Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1.},
  author={R D Nolan and Thomas E. Eling},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 23},
  pages={
          4273-81
        }
}
  • R. D. Nolan, T. Eling
  • Published 1 December 1986
  • Biology, Medicine, Chemistry
  • Biochemical pharmacology
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11 Citations

11 Citations

Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells.
TLDR
Menadione at sublethal doses caused inhibition of prostaglandin synthesis through inactivation of PGH2 synthase by a reactive species resulting from metabolism of menadione by endothelial cells.
Vitamin K2 (menatetrenone) inhibits prostaglandin synthesis in cultured human osteoblast-like periosteal cells by inhibiting prostaglandin H synthase activity.
Mediators Produced by the Endothelial Cell
TLDR
It is proposed that these three mediators form the endothelial defense mechanism against blood-borne cells and chemicals and that breakdown of this barrier results in diseases such as hypertension and atherosclerosis.
Mediators and the anti-thrombotic properties of the vascular endothelium.
TLDR
The role of three mediators synthesized by the vascular endothelium, which are involved in maintaining the surface of the endothelial cells in a non-thrombogenic state, are discussed, which act together to form the endotocyte defence mechanism against adhering blood cells.
Vitamin K1 attenuates hypoxia-induced relaxation of rat carotid artery.
Vitamin K1 (phylloquinone) induces vascular endothelial dysfunction: role of oxidative stress.
Influence of vitamin K2 on lipid precursors of inflammation and fatty acids pathway activities in HepG2 cells.
Increased production of prostacyclin after injury to the microvasculature in uraemic patients.
  • W. Slazus
  • Medicine, Biology
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 1992
A recently described method to evaluate the primary haemostatic mechanism under in vivo conditions was utilised to investigate thromboxane A2 (TXA2) and prostacyclin (PGI2) production by platelets…
Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR-/- mice.
Vitamin K1 Prevents the Effect of Hypoxia on Phenylephrine-Induced Contraction in the Carotid Artery
TLDR
Results show that vitamin K<sub>1</sub> prevents the deleterious vascular effects induced by hypoxia, probably due to its action on endothelial cells.
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References

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Localisation and stimulation of prostacyclin production in vascular cells
TLDR
It is shown that pig aortic endothelial cells, but not aorti smooth muscle cells or fibroblasts, synthesise PGI2, a novel short-lived metabolite of prostaglandin endoperoxides which is of great importance in the maintenance of vascular homeostasis.
Mechanism of bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells.
Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187.
TLDR
Production of thrombin at a site of vascular injury could, by stimulating PGI(2) synthesis by endothelial cells adjacent to the injured area, limit the number of platelets involved in the primary hemostatic response and help to localize thrombus formation.
Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta
TLDR
Using arterial SMC in culture, it is demonstrated that, in comparison with healthy cultured cells, cells originating from atherosclerotic aorta have a decreased capacity to produce PGI2, suggesting a potential role for PGI 2 in inhibiting the atherosclerosis process.
Prostacyclin synthesis and deacylation of phospholipids in human endothelial cells: comparison of thrombin, histamine and ionophore A23187.
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.
The importance of phospholipase-A2 in prostaglandin biosynthesis.
Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells.
Inhibition of human platelet aggregation by vitamin K.
Ozone inhibits prostacyclin synthesis in pulmonary endothelium.
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