Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1.

  title={Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1.},
  author={R D Nolan and Thomas E. Eling},
  journal={Biochemical pharmacology},
  volume={35 23},
  • R. D. Nolan, T. Eling
  • Published 1 December 1986
  • Biology, Medicine, Chemistry
  • Biochemical pharmacology
11 Citations
Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells.
Menadione at sublethal doses caused inhibition of prostaglandin synthesis through inactivation of PGH2 synthase by a reactive species resulting from metabolism of menadione by endothelial cells.
Mediators Produced by the Endothelial Cell
It is proposed that these three mediators form the endothelial defense mechanism against blood-borne cells and chemicals and that breakdown of this barrier results in diseases such as hypertension and atherosclerosis.
Mediators and the anti-thrombotic properties of the vascular endothelium.
The role of three mediators synthesized by the vascular endothelium, which are involved in maintaining the surface of the endothelial cells in a non-thrombogenic state, are discussed, which act together to form the endotocyte defence mechanism against adhering blood cells.
Increased production of prostacyclin after injury to the microvasculature in uraemic patients.
  • W. Slazus
  • Medicine, Biology
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 1992
A recently described method to evaluate the primary haemostatic mechanism under in vivo conditions was utilised to investigate thromboxane A2 (TXA2) and prostacyclin (PGI2) production by platelets
Vitamin K1 Prevents the Effect of Hypoxia on Phenylephrine-Induced Contraction in the Carotid Artery
Results show that vitamin K<sub>1</sub> prevents the deleterious vascular effects induced by hypoxia, probably due to its action on endothelial cells.


Localisation and stimulation of prostacyclin production in vascular cells
It is shown that pig aortic endothelial cells, but not aorti smooth muscle cells or fibroblasts, synthesise PGI2, a novel short-lived metabolite of prostaglandin endoperoxides which is of great importance in the maintenance of vascular homeostasis.
Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187.
Production of thrombin at a site of vascular injury could, by stimulating PGI(2) synthesis by endothelial cells adjacent to the injured area, limit the number of platelets involved in the primary hemostatic response and help to localize thrombus formation.
Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta
Using arterial SMC in culture, it is demonstrated that, in comparison with healthy cultured cells, cells originating from atherosclerotic aorta have a decreased capacity to produce PGI2, suggesting a potential role for PGI 2 in inhibiting the atherosclerosis process.