Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.

  title={Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.},
  author={Jeremy Griggs and Jeremy N. Skepper and Gerry A Smith and Kevin M Brindle and James C. Metcalfe and Robin Hesketh},
  journal={The American journal of pathology},
  volume={160 3},
Retinal neovascularization occurs in a variety of diseases including diabetic retinopathy, the most common cause of blindness in the developed world. There is accordingly considerable incentive to develop drugs that target the aberrant angiogenesis associated with these conditions. Previous studies have shown that a number of anti-angiogenic agents can inhibit retinal neovascularization in a well-characterized murine model of ischemia-induced proliferative retinopathy. Combretastatin-A4 (CA-4… CONTINUE READING


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