Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice.

@article{Kirchner1975InhibitionOP,
  title={Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice.},
  author={Holger Kirchner and Andrew V Muchmore and Thomas M. Chused and H. T. Holden and Ronald B. Herberman},
  journal={Journal of immunology},
  year={1975},
  volume={114 1 Pt 1},
  pages={206-10}
}
We have recently demonstrated suppressor cells in spleens of mice bearing tumors induced by Moloney murine sarcoma virus (MSV) which were non-T cells and inhibited phytohemagglutinin Molney (PHA)-induced DNA synthesis of syngeneic normal spleen cells. From the present study, the suppressor cells appeared to be macrophages since they were radioresistant, inactivated by carrageenan, and removed by adherence columns and an iron/magnet technique. We have also found that suppressor cells were still… CONTINUE READING