Inhibition of proliferation and stimulation of migration of endothelial cells by secretoneurin in vitro.

@article{Khler1997InhibitionOP,
  title={Inhibition of proliferation and stimulation of migration of endothelial cells by secretoneurin in vitro.},
  author={Christian Matthias K{\"a}hler and Rudolf Kirchmair and Gerhard Kaufmann and Stefan T. Kaehler and Norbert Reinisch and Reiner Fischer-Colbrie and Ruth A. Hogue-Angeletti and Hans - Joachim Kl{\"o}ckers Caroline Willeke Lex Hoogduin J Winkler and Christian J Wiedermann},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 5},
  pages={932-9}
}
Vascular cell responses in inflammation are affected by several neuropeptides of perivascular nerve fibers. Secretoneurin is a 33-amino acid peptide that is coreleased from these nerve endings with other proinflammatory neuropeptides, eg, substance P and calcitonin gene-related peptide. Furthermore, secretoneurin has been shown to be chemotactic for human skin fibroblasts and human blood monocytes in vitro and in vivo. An action on cellular components of the vascular wall is not yet reported… CONTINUE READING