Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.

@article{Stockhammer1995InhibitionOP,
  title={Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.},
  author={Guenther Stockhammer and Geoffrey T. Manley and Robert Johnson and Marc Rosenblum and Dvorit Samid and Frank Lieberman},
  journal={Journal of neurosurgery},
  year={1995},
  volume={83 4},
  pages={
          672-81
        }
}
The authors investigated the effects of a nontoxic differentiation inducer, phenylacetate (PA), on neuroectodermal tumor-derived cell lines. Treatment of medulloblastoma (Daoy and D283 MED) and glioma (U-251MG, C6, and RG2) cell lines resulted in a dose-dependent decline in DNA synthesis and cell proliferation, associated with accumulation in the G0/G1 phase of the cell cycle. Phenylacetate decreased transforming growth factor (TGF)-beta 2 production by medulloblastoma Daoy cells. Neutralizing… CONTINUE READING

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Biodistribution and pharmacokinetics of I-131 labelled 4-iodophenylacetic acid.

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References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

Retinoic acid modulation of proliferation and differentiation in brain tumors

  • A Agrawal, LA Martell, DA Ross
  • Proc Am Assoc Cancer Res
  • 1993