Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.

@article{Jobin1998InhibitionOP,
  title={Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.},
  author={Christian Jobin and Asit Panja and Claus Hellerbrand and Yuji Iimuro and J Didonato and David Brenner and Ryan Balfour Sartor},
  journal={Journal of immunology},
  year={1998},
  volume={160 1},
  pages={410-8}
}
NF-kappaB plays a major role in the transcriptional regulation of many proinflammatory genes in multiple cell lineages, including intestinal epithelial cells (IEC). Activation of NF-kappaB requires both phosphorylation and degradation of its natural cytoplasmic inhibitor, IkappaB. We tested whether a super-repressor of NF-kappaB activity, which is a mutated nondegradable IkappaB alpha resistant to phosphorylation and degradation, could be delivered into IEC using an adenoviral vector (Ad5… CONTINUE READING

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