Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials.

@article{Roux2002InhibitionOP,
  title={Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials.},
  author={P. A. le Roux and S. Tregoning and P. Zinn and Z. M. van der Spuy},
  journal={Human reproduction},
  year={2002},
  volume={17 6},
  pages={
          1483-9
        }
}
  • P. A. le Roux, S. Tregoning, +1 author Z. M. van der Spuy
  • Published 2002
  • Medicine
  • Human reproduction
  • BACKGROUND Progesterone is central to the maintenance of pregnancy, and is thus the ideal target for fertility regulation. Two mechanisms by which progesterone can be targeted are: receptor blockade and reduction of progesterone production through enzyme inhibition. Mifepristone, a receptor blocker, is usually given as 'pretreatment' prior to prostaglandin administration in mid-trimester termination of pregnancy (TOP). Unfortunately, there are difficulties accessing mifepristone in developing… CONTINUE READING
    16 Citations
    Effects of arecoline on testosterone release in rats.
    • 14
    • PDF
    Expression of progesterone receptor A form and its role in the interaction of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts.
    • 8
    • PDF
    The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea—an in vitro study
    • 1
    Assisted reproduction technologies alter steroid delivery to the mouse fetus during pregnancy
    • 19
    Medical methods for mid-trimester termination of pregnancy.
    • 66
    Treatment of canine Alopecia X with trilostane.
    • 26
    The use of trilostane for the treatment of alopecia X in Alaskan malamutes.
    • 13

    References

    SHOWING 1-10 OF 32 REFERENCES
    Interruption of first trimester human pregnancy following Epostane therapy. Effect of prostaglandin E2 pessaries
    • 35
    Uterine contractility during pregnancy and the effect of abortifacient drugs.
    • 8
    Termination of early pregnancy by the 3 beta-hydroxysteroid dehydrogenase inhibitor epostane.
    • 10
    Effects of antiprogesterone on pregnancy. I. Midpregnancy.
    • 16
    Use of misoprostol in first and second trimester abortion: a review.
    • 62
    Mifepristone (RU486): a review.
    • 140