• DOI:10.1093/HUMREP/17.6.1483
Corpus ID: 20117000

Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials.

@article{Roux2002InhibitionOP,
  title={Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials.},
  author={P. A. le Roux and S. Tregoning and P. Zinn and Z. M. van der Spuy},
  journal={Human reproduction},
  year={2002},
  volume={17 6},
  pages={
          1483-9
        }
}

P. A. le Roux, S. Tregoning, +1 author Z. M. van der Spuy

Published 2002

Medicine

Human reproduction

BACKGROUND Progesterone is central to the maintenance of pregnancy, and is thus the ideal target for fertility regulation. Two mechanisms by which progesterone can be targeted are: receptor blockade and reduction of progesterone production through enzyme inhibition. Mifepristone, a receptor blocker, is usually given as 'pretreatment' prior to prostaglandin administration in mid-trimester termination of pregnancy (TOP). Unfortunately, there are difficulties accessing mifepristone in developing… CONTINUE READING

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