Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.

@article{Drouineaud2007InhibitionOP,
  title={Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.},
  author={V{\'e}ronique Drouineaud and Paul Sagot and Carmen Garrido and Emmanuelle Logette and Val{\'e}rie Deckert and Philippe Gambert and Cl{\'e}ment Jimenez and Bart Staels and Laurent Lagrost and David R. Masson},
  journal={Molecular human reproduction},
  year={2007},
  volume={13 6},
  pages={373-9}
}
Progesterone production by luteal cells is dependent on the supply of cholesterol by lipoproteins. The aim of this study was to determine whether the liver X receptors (LXRs) contribute to cholesterol homeostasis and progesterone secretion in human luteinized granulosa cells. Cells were isolated from follicular aspirates of patients undergoing in vitro fertilization. Luteinization was induced by a 7-day treatment with human chorionic gonadotrophin. LXR beta was expressed at higher levels than… CONTINUE READING