Inhibition of procollagen C-proteinase: fibrosis and beyond

@article{Turtle2004InhibitionOP,
  title={Inhibition of procollagen C-proteinase: fibrosis and beyond},
  author={Eric D. Turtle and Wen-Bin Ho},
  journal={Expert Opinion on Therapeutic Patents},
  year={2004},
  volume={14},
  pages={1185 - 1197}
}
  • E. Turtle, W. Ho
  • Published 1 August 2004
  • Biology, Medicine
  • Expert Opinion on Therapeutic Patents
Procollagen C-proteinase (PCP) plays a key role in fibrosis. The activity of PCP is necessary to convert soluble procollagens into fully formed collagen fibrils. Fibrosis is a pathological condition in which the normal wound healing process goes awry, culminating in the excessive production and deposition of collagen, a major component of scar tissue. The persistent formation of scar tissue hinders proper tissue function and can lead to organ failure in a wide range of fibrotic diseases. PCP is… 

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