Inhibition of prion amplification by expression of dominant inhibitory mutants--a systematic insertion mutagenesis study.

@article{Geissen2009InhibitionOP,
  title={Inhibition of prion amplification by expression of dominant inhibitory mutants--a systematic insertion mutagenesis study.},
  author={Markus Geissen and Harriet Mella and Armin Saalmueller and Martin Eiden and Juliane Proft and Eberhard Pfaff and Hermann M Sch{\"a}tzl and Martin H Groschup},
  journal={Infectious disorders drug targets},
  year={2009},
  volume={9 1},
  pages={40-7}
}
Until now it is still not clear which structural elements of the prion protein (PrP) are involved in its conversion process. Characterisation of these essential regions would help to understand the conversion process itself and might help to develop specific therapeutic approaches to inhibit PrP(res) formation by dominant inhibitory mutations. To address… CONTINUE READING