Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates.

@article{Shamay2015InhibitionOP,
  title={Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates.},
  author={Yosi Shamay and Lior Raviv and M Hava Golan and Elena Voronov and Ron N. Apte and Ayelet David},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={217},
  pages={102-12}
}
There is currently no effective means to prevent or control metastatic dissemination of cancer cells. E-selectin, an adhesion molecule expressed exclusively on inflamed and angiogenic blood vessels, plays an important role in several rate-limiting steps of cancer metastasis. In this study, we assessed the in vivo antitumor efficacy of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers conjugated to an E-selectin binding peptide (Esbp, DITWDQLWDLMK) and equipped with the chemotherapeutic drug… CONTINUE READING