Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures.

@article{Kim2001InhibitionOP,
  title={Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures.},
  author={H S Kim and Li-fang Liang and Roger Dean and Dorothy B. Hausman and Diane L. Hartzell and Clifton A. Baile},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={281 4},
  pages={902-6}
}
Myostatin, a new TGF-beta family member, is known as a muscle growth inhibitor, but its role in adipocyte development has not been studied. To test the role of Myostatin in 3T3-L1 preadipocyte differentiation, we treated cultured 3T3-L1 preadipocytes with Myostatin dissolved in 0.1% trifluoroacetic acid (TFA) during differentiation after they had become confluent. Myostatin treatment significantly decreased glycerol-3-phosphate dehydrogenase (GPDH) activity and oil Red-O staining compared to… CONTINUE READING
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