Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics

Abstract

The calcium-activated phosphodiesteratic hydrolysis of32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasing concentrations of Ca2+, indicating… (More)
DOI: 10.1007/BF00965878

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