Inhibition of polymorphonuclear leukocyte respiratory burst by elevated glucose concentrations in vitro.

@article{Nielson1989InhibitionOP,
  title={Inhibition of polymorphonuclear leukocyte respiratory burst by elevated glucose concentrations in vitro.},
  author={Christopher Nielson and D A Hindson},
  journal={Diabetes},
  year={1989},
  volume={38 8},
  pages={1031-5}
}
Although impaired polymorphonuclear leukocyte (PMN) function may be a cause of infectious complications in diabetic patients, the mechanisms of altered cell function are not understood. Our studies of PMN function in healthy subjects demonstrated significant reduction in the respiratory burst after 30 min of in vitro cell exposure to glucose concentrations greater than 11 mM (200 mg/dl). The respiratory burst was reduced 28 +/- 5 and 74 +/- 7% in PMNs incubated with 11 and 56 mM glucose… CONTINUE READING

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