Inhibition of polymer-induced red blood cell aggregation by poloxamer 188.

@article{Tth2000InhibitionOP,
  title={Inhibition of polymer-induced red blood cell aggregation by poloxamer 188.},
  author={Kriszti{\'a}n T{\'o}th and Rosalinda B. Wenby and Herbert J. Meiselman},
  journal={Biorheology},
  year={2000},
  volume={37 4},
  pages={301-12}
}
Previous reports have suggested that non-ionic poloxamer surfactants of appropriate molecular mass and composition can reduce red blood cell (RBC) aggregation in whole blood and in RBC-plasma suspensions. We have thus evaluated this phenomenon for RBC aggregated by several water-soluble polymers, using poloxamer 188 (P188), a non-ionic, tri-block molecule (total molecular mass of 8.40 kDa, 80% polyoxyethylene). Human RBC were washed, then re-suspended in isotonic solutions of dextran 70 (70.3… CONTINUE READING